Q1-2018-BiotechReport

FDA Approvals

FDA DRUG APPROVALS

50

BERG MASS LIFE SCIENCE INDEX E THAN DOUBLED BOTTOMING IN EARLY 2012; ING A PEAK IN EARLY 2018.

45

40

35

30

25

20

15

Life Science

Total

10

$1,020,265,000 $1,090,350,000 $834,680,000 $2,152,600,000 $1,510,700,000 $2,588,000,000 $1,631,600,000 0 5

$1.02 $2,566,844,000 $1,546,579,000 $1.55 $1.09 $2,417,630,000 $1,327,280,000 $1.33 $0.83 $2,552,995,000 $1,718,315,000 $1.72 $2.15 $3,703,510,000 $1,550,910,000 $1.55 $1.51 $2,651,810,000 $1,141,110,000 $1.14 $2.59 $3,977,925,000 $1,389,925,000 $1.39 $1.63 $2,438,000,000 $806,400,000 $0.81

A UG OVALS 1 - 2 0 1 7 )

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

250

MA Venture Capital Funding

109%

MA VC FUNDING

$4.5

$4.0

148

$3.5

$3.0

$2.5

F ROM MASSACHUSETTS COMPANIES

$2.0

$1.5

65%

58%

$1.0

67%

57%

45%

40%

$0.5

33%

$0.0

2012

2013

2014

2015

2016

2017

YTD

Life Science Funding

Total Funding

MA Life Science IPOs MA LIFE SCIENCE IPOs

YTD

2017

2016

2015

2014

2013

2012

$0

$200 $400 $600 $800 $1,000 $1,200 $1,400 $1,600 $1,800

(In Millions)

5